Thousands more NHS patients who are hospitalised due to COVID-19 will be able to receive life-saving treatment tocilizumab, the government has announced.
The drug reduced the relative risk of death by 14% and reduced the time spent in hospital by five days when used for patients on oxygen and in addition to the corticosteroid dexamethasone.
The roll-out of this treatment could also contribute significantly towards reducing pressures on hospitals over the coming weeks and months.
Scientists discovered the drug was effective during the RECOVERY clinical trial, funded by the UK government through the National Institute for Health Research (NIHR) and UK Research and Innovation (UKRI).
Last month, the international clinical trial REMAP-CAP, also funded by the government, found that tocilizumab and sarilumab reduced the risk of death for patients when administered within 24 hours of entering intensive care.
The latest findings by RECOVERY, run by the University of Oxford, show a much larger group of hospitalised patients can also benefit from the drug if it is given to those outside of intensive care with oxygen deficiency and showing signs of worsening – meaning potentially thousands more lives could be saved.
Health and Social Care Secretary Matt Hancock said:
Deputy Chief Medical Officer Professor Jonathan Van-Tam said:
Professor Stephen Powis, NHS national medical director, said:
The government is working closely with the manufacturer Roche to ensure the drug is available across NHS healthcare settings.
This is the second treatment that RECOVERY, the world’s largest randomised controlled clinical trial, has found to be effective against COVID-19. It follows its discovery of the world-first treatment dexamethasone in June last year, which reduces the risk of death by 20% for patients on oxygen and 35% for ventilated patients.
RECOVERY has now found the benefits of using tocilizumab with dexamethasone are in addition to the benefits shown by dexamethasone alone.
Updated guidance will be sent to NHS trusts and clinicians on Monday, recommending they use this drug for hospitalised patients who may benefit from the treatment.
Throughout the pandemic, the government has supported British research with millions of pounds of funding for clinical trials into the most promising and innovative medicines in our fight against the virus, including for the RECOVERY trial.
The considerable success in large-scale clinical trials, like RECOVERY, is due to the UK’s world-class researchers, life sciences industry and research infrastructure, and the willingness of the public to volunteer, as well as existing NIHR infrastructure in NHS hospitals across the country.
With over 35,649 participants, RECOVERY is the largest randomised clinical trial anywhere in the world and will continue to trial other medicines, such as colchicine and baricitinib.
Marius Scholtz, Chief Medical Officer at Roche Products Ltd, said: